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Engineered extracellular vesicles: potentials in most cancers mixture remedy | Journal of Nanobiotechnology

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  • Sullivan R, Maresh G, Zhang X, Salomon C, Hooper J, Margolin D, Li L. The rising roles of extracellular vesicles as communication autos throughout the tumor microenvironment and past. Entrance Endocrinol. 2017;8:194.


    Google Scholar
    Ā 

  • Maacha S, Bhat AA, Jimenez L, Raza A, Haris M, Uddin S, Grivel JC. Extracellular vesicles-mediated intercellular communication: roles within the tumor microenvironment and anti-cancer drug resistance. Mol Most cancers. 2019;18:55.

    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Mathieu M, Martin-Jaular L, Lavieu G, ThĆ©ry C. Specificities of secretion and uptake of exosomes and different extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 2019;21:9–17.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Pirisinu M, Pham TC, Zhang DX, Hong TN, Nguyen LT, Le MT. Extracellular vesicles as pure therapeutic brokers and innate drug supply techniques for most cancers remedy: current advances, present obstacles, and challenges for scientific translation. Semin Most cancers Biol. 2020. https://doi.org/10.1016/j.semcancer.2020.08.007.

    ArticleĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Zhang X, Zhang H, Gu J, Zhang J, Shi H, Qian H, Wang D, Xu W, Pan J, Santos HA. Engineered extracellular vesicles for most cancers remedy. Adv Mater. 2021;33:e2005709.

    PubMedĀ 

    Google Scholar
    Ā 

  • Vader P, Mol E, Pasterkamp G, Schiffelers R. Extracellular vesicles for drug supply. Adv Drug Deliv Rev. 2016;106:148–56.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Liu C, Su C. Design methods and utility progress of therapeutic exosomes. Theranostics. 2019;9:1015–28.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Elsharkasy OM, Nordin JZ, Hagey DW, de Jong OG, Schiffelers RM, Andaloussi SE, Vader P. Extracellular vesicles as drug supply techniques: why and the way? Adv Drug Deliv Rev. 2020;159:332–43.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Wiklander OP, Nordin JZ, O’Loughlin A, Gustafsson Y, Corso G, MƤger I, Vader P, Lee Y, Sork H, Seow Y, et al. Extracellular vesicle in vivo biodistribution is decided by cell supply, route of administration and concentrating on. J Extracell Vesicles. 2015;4:26316.

    PubMedĀ 

    Google Scholar
    Ā 

  • Tsoi KM, MacParland SA, Ma XZ, Spetzler VN, Echeverri J, Ouyang B, Fadel SM, Sykes EA, Goldaracena N, Kaths JM, et al. Mechanism of hard-nanomaterial clearance by the liver. Nat Mater. 2016;15:1212–21.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Veerman RE, Güçlüler Akpinar G, Eldh M, Gabrielsson S. Immune cell-derived extracellular vesicles—capabilities and therapeutic purposes. Developments Mol Med. 2019;25:382–94.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Ma J, Zhang H, Tang Okay, Huang B. Tumor-derived microparticles in tumor immunology and immunotherapy. Eur J Immunol. 2020;50:1653–62.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Liang Q, Bie N, Yong T, Tang Okay, Shi X, Wei Z, Jia H, Zhang X, Zhao H, Huang W, et al. The softness of tumour-cell-derived microparticles regulates their drug-delivery effectivity. Nat Biomed Eng. 2019;3:729–40.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Xiao Y, Yu D. Tumor microenvironment as a therapeutic goal in most cancers. Pharmacol Ther. 2021;221:107753.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Qin SY, Cheng YJ, Lei Q, Zhang AQ, Zhang XZ. Combinational technique for high-performance most cancers chemotherapy. Biomaterials. 2018;171:178–97.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Patel SA, Minn AJ. Mixture most cancers remedy with immune checkpoint blockade: mechanisms and techniques. Immunity. 2018;48:417–33.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Shaverdian N, Lisberg AE, Bornazyan Okay, Veruttipong D, Goldman JW, Formenti SC, Garon EB, Lee P. Earlier radiotherapy and the scientific exercise and toxicity of pembrolizumab within the remedy of non-small-cell lung most cancers: a secondary evaluation of the KEYNOTE-001 section 1 trial. Lancet Oncol. 2017;18:895–903.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Gandhi L, RodrĆ­guez-Abreu D, Gadgeel S, Esteban E, Felip E, De Angelis F, Domine M, Clingan P, Hochmair MJ, Powell SF, et al. Pembrolizumab plus chemotherapy in metastatic non-small-cell lung most cancers. N Engl J Med. 2018;378:2078–92.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • van Niel G, D’Angelo G, Raposo G. Shedding mild on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19:213–28.

    PubMedĀ 

    Google Scholar
    Ā 

  • Ridger VC, Boulanger CM, Angelillo-Scherrer A, Badimon L, Blanc-Brude O, Bochaton-Piallat ML, Boilard E, Buzas EI, Caporali A, Dignat-George F, et al. Microvesicles in vascular homeostasis and ailments. Place Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology. Thromb Haemost. 2017;117:1296–316.

    PubMedĀ 

    Google Scholar
    Ā 

  • Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and associates. J Cell Biol. 2013;200:373–83.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Kalluri R, LeBleu VS. The biology, perform, and biomedical purposes of exosomes. Science. 2020. https://doi.org/10.1126/science.aau6977.

    ArticleĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Teng F, Fussenegger M. Shedding mild on extracellular vesicle biogenesis and bioengineering. Adv Sci. 2020;8:2003505.


    Google Scholar
    Ā 

  • Rufino-Ramos D, Albuquerque PR, Carmona V, Perfeito R, Nobre RJ, de Almeida LP. Extracellular vesicles: novel promising supply techniques for remedy of mind ailments. J Management Launch. 2017;262:247–58.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Armstrong JP, Holme MN, Stevens MM. Re-engineering extracellular vesicles as good nanoscale therapeutics. ACS Nano. 2017;11:69–83.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Kooijmans SAA, Stremersch S, Braeckmans Okay, de Smedt SC, Hendrix A, Wooden MJA, Schiffelers RM, Raemdonck Okay, Vader P. Electroporation-induced siRNA precipitation obscures the effectivity of siRNA loading into extracellular vesicles. J Management Launch. 2013;172:229–38.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Haney MJ, Klyachko NL, Zhao Y, Gupta R, Plotnikova EG, He Z, Patel T, Piroyan A, Sokolsky M, Kabanov AV, Batrakova EV. Exosomes as drug supply autos for Parkinson’s illness remedy. J Management Launch. 2015;207:18–30.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Kim MS, Haney MJ, Zhao Y, Mahajan V, Deygen I, Klyachko NL, Inskoe E, Piroyan A, Sokolsky M, Okolie O, et al. Improvement of exosome-encapsulated paclitaxel to beat MDR in most cancers cells. Nanomedicine. 2016;12:655–64.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Fuhrmann G, Serio A, Mazo M, Nair R, Stevens MM. Energetic loading into extracellular vesicles considerably improves the mobile uptake and photodynamic impact of porphyrins. J Management Launch. 2015;205:35–44.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Zhuang X, Xiang X, Grizzle W, Solar D, Zhang S, Axtell RC, Ju S, Mu J, Zhang L, Steinman L, et al. Remedy of mind inflammatory ailments by delivering exosome encapsulated anti-inflammatory medication from the nasal area to the mind. Mol Ther. 2011;19:1769–79.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Hu L, Wickline SA, Hood JL. Magnetic resonance imaging of melanoma exosomes in lymph nodes. Magn Reson Med. 2015;74:266–71.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Jia G, Han Y, An Y, Ding Y, He C, Wang X, Tang Q. NRP-1 focused and cargo-loaded exosomes facilitate simultaneous imaging and remedy of glioma in vitro and in vivo. Biomaterials. 2018;178:302–16.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Pan X, Liang Z, Li J, Wang S, Kong F, Xu Okay, Tang B. Energetic-site-matched fluorescent probes for fast and direct detection of vicinal-sulfydryl-containing peptides/proteins in dwelling cells. Chemistry. 2015;21:2117–22.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Zhao H, Zhao B, Wu L, Xiao H, Ding Okay, Zheng C, Track Q, Solar L, Wang L, Zhang Z. Amplified most cancers immunotherapy of a surface-engineered antigenic microparticle vaccine by synergistically modulating tumor microenvironment. ACS Nano. 2019;13:12553–66.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Fan Z, Xiao Okay, Lin J, Liao Y, Huang X. Functionalized DNA permits programming exosomes/vesicles for tumor imaging and remedy. Small. 2019;15:e1903761.

    PubMedĀ 

    Google Scholar
    Ā 

  • Lin Y, Wu J, Gu W, Huang Y, Tong Z, Huang L, Tan J. Exosome-liposome hybrid nanoparticles ship CRISPR/Cas9 system in MSCs. Adv Sci. 2018;5:1700611.


    Google Scholar
    Ā 

  • Piffoux M, Silva AKA, Wilhelm C, Gazeau F, Tareste D. Modification of extracellular vesicles by fusion with liposomes for the design of customized biogenic drug supply techniques. ACS Nano. 2018;12:6830–42.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • VĆ”zquez-RĆ­os AJ, Molina-Crespo Ɓ, Bouzo BL, López-López R, Moreno-Bueno G, de la Fuente M. Exosome-mimetic nanoplatforms for focused most cancers drug supply. J Nanobiotechnol. 2019;17:85.


    Google Scholar
    Ā 

  • Pan S, Zhang Y, Huang M, Deng Z, Zhang A, Pei L, Wang L, Zhao W, Ma L, Zhang Q, Cui D. Urinary exosomes-based engineered nanovectors for homologously focused chemo-chemodynamic prostate most cancers remedy through abrogating EGFR/AKT/NF-kB/IkB signaling. Biomaterials. 2021;275:120946.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Cheng G, Li W, Ha L, Han X, Hao S, Wan Y, Wang Z, Dong F, Zou X, Mao Y, Zheng SY. Self-assembly of extracellular vesicle-like metal-organic framework nanoparticles for defense and intracellular supply of biofunctional proteins. J Am Chem Soc. 2018;140:7282–91.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Liu C, Zhang W, Li Y, Chang J, Tian F, Zhao F, Ma Y, Solar J. Microfluidic sonication to assemble exosome membrane-coated nanoparticles for immune evasion-mediated concentrating on. Nano Lett. 2019;19:7836–44.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Smyth T, Kullberg M, Malik N, Smith-Jones P, Graner MW, Anchordoquy TJ. Biodistribution and supply effectivity of unmodified tumor-derived exosomes. J Management Launch. 2015;199:145–55.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Wang B, Yao Okay, Huuskes BM, Shen HH, Zhuang J, Godson C, Brennan EP, Wilkinson-Berka JL, Smart AF, Ricardo SD. Mesenchymal stem cells ship exogenous microRNA-let7c through exosomes to attenuate renal fibrosis. Mol Ther. 2016;24:1290–301.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Ohno S, Takanashi M, Sudo Okay, Ueda S, Ishikawa A, Matsuyama N, Fujita Okay, Mizutani T, Ohgi T, Ochiya T, et al. Systemically injected exosomes focused to EGFR ship antitumor microRNA to breast most cancers cells. Mol Ther. 2013;21:185–91.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Lv Q, Cheng L, Lu Y, Zhang X, Wang Y, Deng J, Zhou J, Liu B, Liu J. Thermosensitive exosome-liposome hybrid nanoparticle-mediated chemoimmunotherapy for improved remedy of metastatic peritoneal most cancers. Adv Sci. 2020;7:2000515.

    CASĀ 

    Google Scholar
    Ā 

  • Guo M, Wu F, Hu G, Chen L, Xu J, Xu P, Wang X, Li Y, Liu S, Zhang S, et al. Autologous tumor cell-derived microparticle-based focused chemotherapy in lung most cancers sufferers with malignant pleural effusion. Sci Transl Med. 2019. https://doi.org/10.1126/scitranslmed.aat5690.

    ArticleĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Housman G, Byler S, Heerboth S, Lapinska Okay, Longacre M, Snyder N, Sarkar S. Drug resistance in most cancers: an outline. Cancers. 2014;6:1769–92.

    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Kunjachan S, Rychlik B, Storm G, Kiessling F, Lammers T. Multidrug resistance: physiological ideas and nanomedical options. Adv Drug Deliv Rev. 2013;65:1852–65.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Saraswathy M, Gong S. Totally different methods to beat multidrug resistance in most cancers. Biotechnol Adv. 2013;31:1397–407.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Dong J, Qin Z, Zhang WD, Cheng G, Yehuda AG, Ashby CR Jr, Chen ZS, Cheng XD, Qin JJ. Medicinal chemistry methods to find P-glycoprotein inhibitors: an replace. Drug Resist Updat. 2020;49:100681.

    PubMedĀ 

    Google Scholar
    Ā 

  • Wang T, Luo Y, Lv H, Wang J, Zhang Y, Pei R. Aptamer-based erythrocyte-derived mimic vesicles loaded with siRNA and doxorubicin for the focused remedy of multidrug-resistant tumors. ACS Appl Mater Interfaces. 2019;11:45455–66.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Ma J, Zhang Y, Tang Okay, Zhang H, Yin X, Li Y, Xu P, Solar Y, Ma R, Ji T, et al. Reversing drug resistance of soppy tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles. Cell Res. 2016;26:713–27.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Jin X, Ma J, Liang X, Tang Okay, Liu Y, Yin X, Zhang Y, Zhang H, Xu P, Chen D, et al. Pre-instillation of tumor microparticles enhances intravesical chemotherapy of nonmuscle-invasive bladder most cancers by means of a lysosomal pathway. Biomaterials. 2017;113:93–104.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Yong T, Zhang X, Bie N, Zhang H, Zhang X, Li F, Hakeem A, Hu J, Gan L, Santos HA, Yang X. Tumor exosome-based nanoparticles are environment friendly drug carriers for chemotherapy. Nat Commun. 2019;10:3838.

    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Liu J, Ye Z, Xiang M, Chang B, Cui J, Ji T, Zhao L, Li Q, Deng Y, Xu L, et al. Practical extracellular vesicles engineered with lipid-grafted hyaluronic acid successfully reverse most cancers drug resistance. Biomaterials. 2019;223:119475.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Kurozumi S, Yamaguchi Y, Kurosumi M, Ohira M, Matsumoto H, Horiguchi J. Current tendencies in microRNA analysis into breast most cancers with explicit deal with the associations between microRNAs and intrinsic subtypes. J Hum Genet. 2017;62:15–24.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Wang S, Su X, Bai H, Zhao J, Duan J, An T, Zhuo M, Wang Z, Wu M, Li Z, et al. Identification of plasma microRNA profiles for major resistance to EGFR-TKIs in superior non-small cell lung most cancers (NSCLC) sufferers with EGFR activating mutation. J Hematol Oncol. 2015;8:127.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, et al. MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci USA. 2010;107:21098–103.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Penna E, Orso F, Taverna D. miR-214 as a key hub that controls most cancers networks: small participant, a number of capabilities. J Make investments Dermatol. 2015;135:960–9.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Liang G, Zhu Y, Ali DJ, Tian T, Xu H, Si Okay, Solar B, Chen B, Xiao Z. Engineered exosomes for focused co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon most cancers. J Nanobiotechnol. 2020;18:10.

    CASĀ 

    Google Scholar
    Ā 

  • Wang X, Zhang H, Bai M, Ning T, Ge S, Deng T, Liu R, Zhang L, Ying G, Ba Y. Exosomes function nanoparticles to ship anti-miR-214 to reverse chemoresistance to cisplatin in gastric most cancers. Mol Ther. 2018;26:774–83.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Bose RJC, Uday Kumar S, Zeng Y, Afjei R, Robinson E, Lau Okay, Bermudez A, Habte F, Pitteri SJ, Sinclair R, et al. Tumor cell-derived extracellular vesicle-coated nanocarriers: an environment friendly theranostic platform for the cancer-specific supply of anti-miR-21 and imaging brokers. ACS Nano. 2018;12:10817–32.

    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Lyu Y, Li J, Pu Okay. Second near-infrared absorbing brokers for photoacoustic imaging and photothermal remedy. Small Strategies. 2019. https://doi.org/10.1002/smtd.201900553.

    ArticleĀ 

    Google Scholar
    Ā 

  • Spiliotis J, Halkia E, de Bree E. Remedy of peritoneal floor malignancies with hyperthermic intraperitoneal chemotherapy-current views. Curr Oncol. 2016;23:e266-275.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Zeng X, Luo M, Liu G, Wang X, Tao W, Lin Y, Ji X, Nie L, Mei L. Polydopamine-modified black phosphorous nanocapsule with enhanced stability and photothermal efficiency for tumor multimodal remedies. Adv Sci. 2018;5:1800510.


    Google Scholar
    Ā 

  • Zhang Z, Wang J, Chen C. Close to-infrared light-mediated nanoplatforms for most cancers thermo-chemotherapy and optical imaging. Adv Mater. 2013;25:3869–80.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Zhang D, Qin X, Wu T, Qiao Q, Track Q, Zhang Z. Extracellular vesicles based mostly self-grown gold nanopopcorn for combinatorial chemo-photothermal remedy. Biomaterials. 2019;197:220–8.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Wang D, Yao Y, He J, Zhong X, Li B, Rao S, Yu H, He S, Feng X, Xu T, et al. Engineered cell-derived microparticles Bi(2)Se(3)/DOX@MPs for imaging guided synergistic photothermal/low-dose chemotherapy of most cancers. Adv Sci. 2020;7:1901293.

    CASĀ 

    Google Scholar
    Ā 

  • Zhu L, Wang C, Pang DW, Zhang ZL. Managed launch of therapeutic brokers with near-infrared laser for synergistic photochemotherapy towards cervical most cancers. Anal Chem. 2019;91:6555–60.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Tian R, Wang Z, Niu R, Wang H, Guan W, Chang J. Tumor exosome mimicking nanoparticles for tumor combinatorial chemo-photothermal remedy. Entrance Bioeng Biotechnol. 2020;8:1010.

    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Zhou Z, Liu X, Zhu D, Wang Y, Zhang Z, Zhou X, Qiu N, Chen X, Shen Y. Nonviral most cancers gene remedy: supply cascade and vector nanoproperty integration. Adv Drug Deliv Rev. 2017;115:115–54.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Zhuo C, Zhang J, Lee JH, Jiao J, Cheng D, Liu L, Kim HW, Tao Y, Li M. Spatiotemporal management of CRISPR/Cas9 gene modifying. Sign Transduct Goal Ther. 2021;6:238.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Kim SM, Yang Y, Oh SJ, Hong Y, Search engine optimisation M, Jang M. Most cancers-derived exosomes as a supply platform of CRISPR/Cas9 confer most cancers cell tropism-dependent concentrating on. J Management Launch. 2017;266:8–16.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Montero J, Letai A. Why do BCL-2 inhibitors work and the place ought to we use them within the clinic? Cell Loss of life Differ. 2018;25:56–64.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Zhu L, Dong D, Yu ZL, Zhao YF, Pang DW, Zhang ZL. Folate-engineered microvesicles for enhanced goal and synergistic remedy towards breast most cancers. ACS Appl Mater Interfaces. 2017;9:5100–8.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Kemp JA, Shim MS, Heo CY, Kwon YJ. ā€œComboā€ nanomedicine: co-delivery of multi-modal therapeutics for environment friendly, focused, and protected most cancers remedy. Adv Drug Deliv Rev. 2016;98:3–18.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Gupta J, Safdari HA, Hoque M. Nanoparticle mediated most cancers immunotherapy. Semin Most cancers Biol. 2021;69:307–24.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Liu J, Zhang R, Xu ZP. Nanoparticle-based nanomedicines to advertise most cancers immunotherapy: current advances and future instructions. Small. 2019;15:e1900262.

    PubMedĀ 

    Google Scholar
    Ā 

  • Inexperienced JJ, Elisseeff JH. Mimicking organic performance with polymers for biomedical purposes. Nature. 2016;540:386–94.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Maeda H, Nakamura H, Fang J. The EPR impact for macromolecular drug supply to strong tumors: enchancment of tumor uptake, reducing of systemic toxicity, and distinct tumor imaging in vivo. Adv Drug Deliv Rev. 2013;65:71–9.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Wang Okay, Ye H, Zhang X, Wang X, Yang B, Luo C, Zhao Z, Zhao J, Lu Q, Zhang H, et al. An exosome-like programmable-bioactivating paclitaxel prodrug nanoplatform for enhanced breast most cancers metastasis inhibition. Biomaterials. 2020;257:120224.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Li S, Wu Y, Ding F, Yang J, Li J, Gao X, Zhang C, Feng J. Engineering macrophage-derived exosomes for focused chemotherapy of triple-negative breast most cancers. Nanoscale. 2020;12:10854–62.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Gotwals P, Cameron S, Cipolletta D, Cremasco V, Crystal A, Hewes B, Mueller B, Quaratino S, Sabatos-Peyton C, Petruzzelli L, et al. Prospects for combining focused and standard most cancers remedy with immunotherapy. Nat Rev Most cancers. 2017;17:286–301.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Smyth MJ, Ngiow SF, Ribas A, Teng MW. Mixture most cancers immunotherapies tailor-made to the tumour microenvironment. Nat Rev Clin Oncol. 2016;13:143–58.

    CASĀ 

    Google Scholar
    Ā 

  • Lindenbergh MFS, Stoorvogel W. Antigen presentation by extracellular vesicles from skilled antigen-presenting cells. Annu Rev Immunol. 2018;36:435–59.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Yan W, Jiang S. Immune cell-derived exosomes within the cancer-immunity cycle. Developments Most cancers. 2020;6:506–17.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Choo YW, Kang M, Kim HY, Han J, Kang S, Lee JR, Jeong GJ, Kwon SP, Track SY, Go S, et al. M1 macrophage-derived nanovesicles potentiate the anticancer efficacy of immune checkpoint inhibitors. ACS Nano. 2018;12:8977–93.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Matsumoto A, Asuka M, Takahashi Y, Takakura Y. Antitumor immunity by small extracellular vesicles collected from activated dendritic cells by means of efficient induction of mobile and humoral immune responses. Biomaterials. 2020;252:120112.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Nikfarjam S, Rezaie J, Kashanchi F, Jafari R. Dexosomes as a cell-free vaccine for most cancers immunotherapy. J Exp Clin Most cancers Res. 2020;39:258.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Pitt JM, AndrĆ© F, Amigorena S, Soria JC, Eggermont A, Kroemer G, Zitvogel L. Dendritic cell-derived exosomes for most cancers remedy. J Clin Make investments. 2016;126:1224–32.

    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Fu W, Lei C, Liu S, Cui Y, Wang C, Qian Okay, Li T, Shen Y, Fan X, Lin F, et al. CAR exosomes derived from effector CAR-T cells have potent antitumour results and low toxicity. Nat Commun. 2019;10:4355.

    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Ugel S, CanĆØ S, De Sanctis F, Bronte V. Monocytes within the tumor microenvironment. Annu Rev Pathol. 2021;16:93–122.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • DeNardo DG, Ruffell B. Macrophages as regulators of tumour immunity and immunotherapy. Nat Rev Immunol. 2019;19:369–82.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Zitvogel L, Galluzzi L, Smyth MJ, Kroemer G. Mechanism of motion of typical and focused anticancer therapies: reinstating immunosurveillance. Immunity. 2013;39:74–88.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Galluzzi L, Buque A, Kepp O, Zitvogel L, Kroemer G. Immunogenic cell dying in most cancers and infectious illness. Nat Rev Immunol. 2017;17:97–111.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Zhou W, Zhou Y, Chen X, Ning T, Chen H, Guo Q, Zhang Y, Liu P, Zhang Y, Li C, et al. Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment. Biomaterials. 2021;268:120546.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Chang M, Hou Z, Wang M, Li C, Lin J. Current advances in hyperthermia therapy-based synergistic immunotherapy. Adv Mater. 2021;33:e2004788.

    PubMedĀ 

    Google Scholar
    Ā 

  • Alzeibak R, Mishchenko TA, Shilyagina NY, Balalaeva IV, Vedunova MV, Krysko DV. Concentrating on immunogenic most cancers cell dying by photodynamic remedy: previous, current and future. J Immunother Most cancers. 2021. https://doi.org/10.1136/jitc-2020-001926.

    ArticleĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Pinto A, Marangon I, MĆ©reaux J, NicolĆ”s-Boluda A, Lavieu G, Wilhelm C, Sarda-Mantel L, Silva AKA, Pocard M, Gazeau F. Immune reprogramming precision photodynamic remedy of peritoneal metastasis by scalable stem-cell-derived extracellular vesicles. ACS Nano. 2021;15:3251–63.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Cheng L, Zhang X, Tang J, Lv Q, Liu J. Gene-engineered exosomes-thermosensitive liposomes hybrid nanovesicles by the blockade of CD47 sign for mixed photothermal remedy and most cancers immunotherapy. Biomaterials. 2021;275:120964.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Bagchi S, Yuan R, Engleman EG. Immune checkpoint inhibitors for the remedy of most cancers: scientific impression and mechanisms of response and resistance. Annu Rev Pathol. 2021;16:223–49.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Jones KI, Tiersma J, Yuzhalin AE, Gordon-Weeks AN, Buzzelli J, Im JH, Muschel RJ. Radiation mixed with macrophage depletion promotes adaptive immunity and potentiates checkpoint blockade. EMBO Mol Med. 2018. https://doi.org/10.15252/emmm.201809342.

    ArticleĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Wu Q, Zhou W, Yin S, Zhou Y, Chen T, Qian J, Su R, Hong L, Lu H, Zhang F, et al. Blocking triggering receptor expressed on myeloid cells-1-positive tumor-associated macrophages induced by hypoxia reverses immunosuppression and anti-programmed cell dying ligand 1 resistance in liver most cancers. Hepatology. 2019;70:198–214.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Wei Z, Zhang X, Yong T, Bie N, Zhan G, Li X, Liang Q, Li J, Yu J, Huang G, et al. Boosting anti-PD-1 remedy with metformin-loaded macrophage-derived microparticles. Nat Commun. 2021;12:440.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Saxena M, van der Burg SH, Melief CJM, Bhardwaj N. Therapeutic most cancers vaccines. Nat Rev Most cancers. 2021;21:360–78.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Hu Z, Ott PA, Wu CJ. In the direction of customized, tumour-specific, therapeutic vaccines for most cancers. Nat Rev Immunol. 2018;18:168–82.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Morishita M, Takahashi Y, Matsumoto A, Nishikawa M, Takakura Y. Exosome-based tumor antigens-adjuvant co-delivery using genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA. Biomaterials. 2016;111:55–65.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Damo M, Wilson DS, Simeoni E, Hubbell JA. TLR-3 stimulation improves anti-tumor immunity elicited by dendritic cell exosome-based vaccines in a murine mannequin of melanoma. Sci Rep. 2015;5:17622.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Wahlund CJE, Güclüler G, Hiltbrunner S, Veerman RE, NƤslund TI, Gabrielsson S. Exosomes from antigen-pulsed dendritic cells induce stronger antigen-specific immune responses than microvesicles in vivo. Sci Rep. 2017;7:17095.

    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Zitvogel L, Regnault A, Lozier A, Wolfers J, Flament C, Tenza D, Ricciardi-Castagnoli P, Raposo G, Amigorena S. Eradication of established murine tumors utilizing a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med. 1998;4:594–600.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Abdulrahman Z, de Miranda N, van Esch EMG, de Vos van Steenwijk PJ, Nijman HW, Marij JPW, van Poelgeest MIE, van der Burg SH. Pre-existing inflammatory immune microenvironment predicts the scientific response of vulvar high-grade squamous intraepithelial lesions to therapeutic HPV16 vaccination. J Immunother Most cancers. 2020. https://doi.org/10.1136/jitc-2020-000563.

    ArticleĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Ott PA, Hu-Lieskovan S, Chmielowski B, Govindan R, Naing A, Bhardwaj N, Margolin Okay, Awad MM, Hellmann MD, Lin JJ, et al. A Part Ib trial of customized neoantigen remedy plus anti-PD-1 in sufferers with superior melanoma, non-small cell lung most cancers, or bladder most cancers. Cell. 2020;183:347-362.e324.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Koerner J, Horvath D, Herrmann VL, MacKerracher A, Gander B, Yagita H, Rohayem J, Groettrup M. PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for efficient anti-cancer immunotherapy. Nat Commun. 2021;12:2935.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Phung CD, Pham TT, Nguyen HT, Nguyen TT, Ou W, Jeong JH, Choi HG, Ku SK, Yong CS, Kim JO. Anti-CTLA-4 antibody-functionalized dendritic cell-derived exosomes concentrating on tumor-draining lymph nodes for efficient induction of antitumor T-cell responses. Acta Biomater. 2020;115:371–82.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Cao Y, Wu T, Zhang Okay, Meng X, Dai W, Wang D, Dong H, Zhang X. Engineered exosome-mediated near-infrared-II area V(2)C quantum dot supply for nucleus-target low-temperature photothermal remedy. ACS Nano. 2019;13:1499–510.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Zhou Y, Yu W, Cao J, Gao H. Harnessing carbon monoxide-releasing platforms for most cancers remedy. Biomaterials. 2020;255:120193.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Zhu D, Liu Z, Li Y, Huang Q, Xia L, Li Okay. Supply of manganese carbonyl to the tumor microenvironment utilizing tumor-derived exosomes for most cancers gasoline remedy and low dose radiotherapy. Biomaterials. 2021;274:120894.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Ding J, Lu G, Nie W, Huang LL, Zhang Y, Fan W, Wu G, Liu H, Xie HY. Self-activatable photo-extracellular vesicle for synergistic trimodal anticancer remedy. Adv Mater. 2021;33:e2005562.

    PubMedĀ 

    Google Scholar
    Ā 

  • Wang J, Chen P, Dong Y, Xie H, Wang Y, Soto F, Ma P, Feng X, Du W, Liu BF. Designer exosomes enabling tumor focused environment friendly chemo/gene/photothermal remedy. Biomaterials. 2021;276:121056.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Grangier A, Branchu J, Volatron J, Piffoux M, Gazeau F, Wilhelm C, Silva AKA. Technological advances in the direction of extracellular vesicles mass manufacturing. Adv Drug Deliv Rev. 2021;176:113843.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Mitchell JP, Court docket J, Mason MD, Tabi Z, Clayton A. Elevated exosome manufacturing from tumour cell cultures utilizing the Integra CELLine Tradition System. J Immunol Strategies. 2008;335:98–105.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • de Almeida FM, Bernardes N, Oliveira FD, Costa AC, Fernandes-Platzgummer A, Farinha JP, Rodrigues CAV, Jung S, Tseng RJ, Milligan W, et al. Scalable manufacturing of human mesenchymal stromal cell-derived extracellular vesicles beneath serum-/xeno-free situations in a microcarrier-based bioreactor tradition system. Entrance Cell Dev Biol. 2020;8:553444.


    Google Scholar
    Ā 

  • Haraszti RA, Miller R, Stoppato M, Sere YY, Coles A, Didiot MC, Wollacott R, Sapp E, Dubuke ML, Li X, et al. Exosomes produced from 3D cultures of mscs by tangential stream filtration present greater yield and improved exercise. Mol Ther. 2018;26:2838–47.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Piffoux M, Silva AKA, Lugagne JB, Hersen P, Wilhelm C, Gazeau F. Extracellular vesicle manufacturing loaded with nanoparticles and medicines in a trade-off between loading, yield and purity: in the direction of a customized drug supply system. Adv Biosyst. 2017;1:e1700044.

    PubMedĀ 

    Google Scholar
    Ā 

  • Yuana Y, Oosterkamp TH, Bahatyrova S, Ashcroft B, Garcia Rodriguez P, Bertina RM, Osanto S. Atomic power microscopy: a novel strategy to the detection of nanosized blood microparticles. J Thromb Haemost. 2010;8:315–23.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Nizamudeen Z, Markus R, Lodge R, Parmenter C, Platt M, Chakrabarti L, Sottile V. Fast and correct evaluation of stem cell-derived extracellular vesicles with tremendous decision microscopy and stay imaging. Biochim Biophys Acta Mol Cell Res. 2018;1865:1891–900.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Corso G, Heusermann W, Trojer D, Gƶrgens A, Steib E, Voshol J, Graff A, Genoud C, Lee Y, Hean J, et al. Systematic characterization of extracellular vesicle sorting domains and quantification on the single molecule—single vesicle degree by fluorescence correlation spectroscopy and single particle imaging. J Extracell Vesicles. 2019;8:1663043.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Choi D, Montermini L, Jeong H, Sharma S, Meehan B, Rak J. Mapping subpopulations of most cancers cell-derived extracellular vesicles and particles by nano-flow cytometry. ACS Nano. 2019;13:10499–511.

    CASĀ 
    PubMedĀ 

    Google Scholar
    Ā 

  • Morales-Kastresana A, Telford B, Musich TA, McKinnon Okay, Clayborne C, Braig Z, Rosner A, Demberg T, Watson DC, Karpova TS, et al. Labeling extracellular vesicles for nanoscale stream cytometry. Sci Rep. 1878;2017:7.


    Google Scholar
    Ā 

  • Daaboul GG, Gagni P, Benussi L, Bettotti P, Ciani M, Cretich M, Freedman DS, Ghidoni R, Ozkumur AY, Piotto C, et al. Digital detection of exosomes by interferometric imaging. Sci Rep. 2016;6:37246.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

  • Silva AM, LĆ”zaro-IbƔƱez E, Gunnarsson A, Dhande A, Daaboul G, Peacock B, Osteikoetxea X, Salmond N, Friis KP, Shatnyeva O, Dekker N. Quantification of protein cargo loading into engineered extracellular vesicles at single-vesicle and single-molecule decision. J Extracell Vesicles. 2021;10:e12130.

    CASĀ 
    PubMedĀ 
    PubMed CentralĀ 

    Google Scholar
    Ā 

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