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A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy | Journal of Nanobiotechnology

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  • 1.

    Fan W, Lu N, Shen Z, Tang W, Shen B, Cui Z, Shan L, Yang Z, Wang Z, Jacobson O. Generic synthesis of small-sized hole mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic remedy. Nat Commun. 2019;10:1241.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • 2.

    Haume Okay, Rosa S, Grellet S, Smialek MA, Butterworth KT, Solov’yov AV, Prise KM, Golding J, Mason NJ. Gold nanoparticles for most cancers radiotherapy: a evaluate. Most cancers Nanotechnol. 2016;7:8.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • 3.

    Tune G, Cheng L, Chao Y, Yang Okay, Liu Z. Rising nanotechnology and superior supplies for most cancers radiation remedy. Adv Mater. 2017;29:1700996.


    Google Scholar
     

  • 4.

    Cao J, Shi X, Gurav DD, Huang L, Su H, Li Okay, Niu J, Zhang M, Wang Q, Jiang M, Qian Okay. Metabolic fingerprinting on artificial alloys for medulloblastoma analysis and radiotherapy analysis. Adv Mater. 2020;32:2000906.

    CAS 

    Google Scholar
     

  • 5.

    Liu J, Hu F, Wu M, Tian L, Gong F, Zhong X, Chen M, Liu Z, Liu B. Bioorthogonal coordination polymer nanoparticles with aggregation-induced emission for deep tumor-penetrating radio- and radiodynamic remedy. Adv Mater. 2021;33:2007888.

    CAS 

    Google Scholar
     

  • 6.

    Sharma RA, Plummer R, Inventory JK, Greenhalgh TA, Ataman O, Kelly S, Clay R, Adams RA, Baird RD, Billingham L. Medical growth of recent drug-radiotherapy combos. Nat Rev Clin Oncol. 2016;13:627–42.

    CAS 
    PubMed 

    Google Scholar
     

  • 7.

    Bian Z, Shi L, Kidder Okay, Zen Okay, Charlie G-B, Liu Y. Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells beneath radiotherapy. Nat Commun. 2021;12:3229.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • 8.

    Fu W, Zhang X, Mei L, Zhou R, Yin W, Wang Q, Gu Z, Zhao Y. Stimuli-responsive small-on-large nanoradiosensitizer for enhanced tumor penetration and radiotherapy sensitization. ACS Nano. 2020;14:10001–17.

    CAS 
    PubMed 

    Google Scholar
     

  • 9.

    Chen X, Tune J, Chen X, Yang H. X-ray-activated nanosystems for theranostic purposes. Chem Soc Rev. 2019;48:3073–101.

    CAS 
    PubMed 

    Google Scholar
     

  • 10.

    Cheng Okay, Sano M, Jenkins CH, Zhang G, Vernekohl D, Zhao W, Wei C, Zhang Y, Zhang Z, Liu Y. Synergistically enhancing the therapeutic impact of radiation remedy with radiation activatable and reactive oxygen species-releasing nanostructures. ACS Nano. 2018;12:4946–58.

    CAS 
    PubMed 

    Google Scholar
     

  • 11.

    Luo D, Wang X, Zeng S, Ramamurthy G, Burda C, Basilion JP. Focused gold nanocluster-enhanced radiotherapy of prostate most cancers. Small. 2019;15:1900968.


    Google Scholar
     

  • 12.

    Xia D, Dangle D, Li Y, Jiang W, Zhu J, Ding Y, Gu H, Hu Y. Au-hemoglobin loaded platelet assuaging tumor hypoxia and enhancing the radiotherapy impact with low-dose X-ray. ACS Nano. 2020;14:15654–68.

    PubMed 

    Google Scholar
     

  • 13.

    Franze B, Engelhard C. Quick separation, characterization, and speciation of gold and silver nanoparticles and their ionic counterparts with micellar electrokinetic chromatography coupled to ICP-MS. Anal Chem. 2014;86:5713–20.

    CAS 
    PubMed 

    Google Scholar
     

  • 14.

    Jin R, Zeng C, Zhou M, Chen Y. Atomically exact colloidal steel nanoclusters and nanoparticles: fundamentals and alternatives. Chem Rev. 2016;116:10346–413.

    CAS 
    PubMed 

    Google Scholar
     

  • 15.

    Kang X, Li Y, Zhu M, Jin R. Atomically exact alloy nanoclusters: syntheses, buildings, and properties. Chem Soc Rev. 2020;49:6443–514.

    PubMed 

    Google Scholar
     

  • 16.

    Liu L, Corma A. Metallic catalysts for heterogeneous catalysis: from single atoms to nanoclusters and nanoparticles. Chem Rev. 2018;118:4981–5079.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • 17.

    Zhang XD, Luo Z, Chen J, Shen X, Tune S, Solar Y, Fan S, Fan F, Leong DT, Xie J. Ultrasmall Au(10–12)(SG)(10–12) nanomolecules for top tumor specificity and most cancers radiotherapy. Adv Mater. 2014;26:4565–8.

    CAS 
    PubMed 

    Google Scholar
     

  • 18.

    Zheng Y, Wu J, Jiang H, Wang X. Gold nanoclusters for theranostic purposes. Coord Chem Rev. 2021;431: 213689.

    CAS 

    Google Scholar
     

  • 19.

    Zhang XD, Chen J, Luo Z, Wu D, Shen X, Tune SS, Solar YM, Liu PX, Zhao J, Huo S. Enhanced tumor accumulation of sub-2 nm gold nanoclusters for most cancers radiation remedy. Adv Healthc Mater. 2014;3:133–41.

    CAS 
    PubMed 

    Google Scholar
     

  • 20.

    Jia TT, Yang G, Mo SJ, Wang ZY, Li BJ, Ma W, Guo YX, Chen X, Zhao X, Liu JQ, Zang SQ. Atomically exact gold-levonorgestrel nanocluster as a radiosensitizer for enhanced most cancers remedy. ACS Nano. 2019;13:8320–8.

    CAS 
    PubMed 

    Google Scholar
     

  • 21.

    Zhou Z, Tune J, Nie L, Chen X. Reactive oxygen species producing programs assembly challenges of photodynamic most cancers remedy. Chem Soc Rev. 2016;45:6597–626.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • 22.

    Liu H, Duan X, Lv Y-Okay, Zhu L, Zhang Z, Yu B, Jin Y, Si Y, Wang Z, Li B, Peng P. Encapsulating steel nanoclusters inside porous natural cage in the direction of enhanced radio-sensitivity and solubility. Chem Eng J. 2021;426:130872.

    CAS 

    Google Scholar
     

  • 23.

    Yang B, Chen Y, Shi J. Reactive oxygen species (ROS)-based nanomedicine. Chem Rev. 2019;119:4881–985.

    CAS 
    PubMed 

    Google Scholar
     

  • 24.

    Zhang W, Hu X, Shen Q, Xing D. Mitochondria-specific drug launch and reactive oxygen species burst induced by polyprodrug nanoreactors can improve chemotherapy. Nat Commun. 2019;10:1704.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • 25.

    Hou H, Huang X, Wei G, Xu F, Wang Y, Zhou S. Fenton reaction-assisted photodynamic remedy for most cancers with multifunctional magnetic nanoparticles. ACS Appl Mater Interfaces. 2019;11:29579–92.

    CAS 
    PubMed 

    Google Scholar
     

  • 26.

    Kim J, Cho HR, Jeon H, Kim D, Tune C, Lee N, Choi SH, Hyeon T. Steady O2-evolving MnFe2O4 nanoparticle-anchored mesoporous silica nanoparticles for environment friendly photodynamic remedy in hypoxic most cancers. J Am Chem Soc. 2017;139:10992–5.

    CAS 
    PubMed 

    Google Scholar
     

  • 27.

    Gao L, Zhang Y, Zhao L, Niu W, Tang Y, Gao F, Cai P, Yuan Q, Jiang H, Gao X. A man-made metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging. Sci Adv. 2020;6: eabb1421.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • 28.

    Liu Y, Zhen W, Jin L, Zhang S, Solar G, Zhang T, Xu X, Tune S, Wang Y, Liu J, Zhang H. All-in-one theranostic nanoagent with enhanced reactive oxygen species era and modulating tumor microenvironment skill for efficient tumor eradication. ACS Nano. 2018;12:4886–93.

    CAS 
    PubMed 

    Google Scholar
     

  • 29.

    Dai Y, Yang Z, Cheng S, Wang Z, Zhang R, Zhu G, Wang Z, Yung BC, Tian R, Jacobson O. Poisonous reactive oxygen species enhanced synergistic mixture remedy by self-assembled metal-phenolic community nanoparticles. Adv Mater. 2018;30:1704877.


    Google Scholar
     

  • 30.

    Fan JX, Peng MY, Wang H, Zheng HR, Liu ZL, Li CX, Wang XN, Liu XH, Cheng SX, Zhang XZ. Engineered bacterial bioreactor for tumor remedy by way of fenton-like response with localized H2O2 era. Adv Mater. 2019;31:1808278.


    Google Scholar
     

  • 31.

    Lin LS, Tune J, Tune L, Ke Okay, Liu Y, Zhou Z, Shen Z, Li J, Yang Z, Tang W. Simultaneous Fenton-like ion supply and glutathione depletion by MnO2-based nanoagent to boost chemodynamic remedy. Angew Chem Int Ed. 2018;57:4902–6.

    CAS 

    Google Scholar
     

  • 32.

    Qian X, Zhang J, Gu Z, Chen Y. Nanocatalysts-augmented Fenton chemical response for nanocatalytic tumor remedy. Biomaterials. 2019;211:1–13.

    CAS 
    PubMed 

    Google Scholar
     

  • 33.

    Tune J, Lin L, Yang Z, Zhu R, Zhou Z, Li ZW, Wang F, Chen J, Yang H, Chen X. Self-assembled responsive bilayered vesicles with adjustable oxidative stress for enhanced most cancers imaging and remedy. J Am Chem Soc. 2019;141:8158–70.

    CAS 
    PubMed 

    Google Scholar
     

  • 34.

    Chen C, Tune Z, Zheng X, He Z, Liu B, Huang X, Kong D, Ding D, Tang BZ. AIEgen-based theranostic system: focused imaging of most cancers cells and adjuvant amplification of antitumor efficacy of paclitaxel. Chem Sci. 2017;8:2191–8.

    CAS 
    PubMed 

    Google Scholar
     

  • 35.

    Zhang J, Zou H, Lei J, He B, He X, Herman HYS, Ryan TKK, Jacky WYL, Zheng L, Tang BZ. Multifunctional AuI-based AIEgens: manipulating molecular buildings and boosting particular most cancers cell imaging and theranostics. Angew Chem Int Ed. 2020;59:7097–105.

    CAS 

    Google Scholar
     

  • 36.

    Tavakkoli Yaraki M, Wu M, Middha E, Wu W, Daqiqeh Rezaei S, Liu B, Tan YN. Gold nanostars-AIE theranostic nanodots with enhanced fluorescence and photosensitization in the direction of efficient image-guided photodynamic remedy. Nano-Micro Lett. 2021;13:58.


    Google Scholar
     

  • 37.

    Li Y, Ni H, Zhang H, Zhang H, Clarence C, Chao Ma KSW, Jacky WYL, Ryan TKK, Qian J, Lu X, Tang BZ. ACQ-to-AIE transformation: tuning molecular packing by regioisomerization for two-photon NIR bioimaging. Angew Chem, Int Ed. 2020;59:12822–6.

    CAS 

    Google Scholar
     

  • 38.

    Kang M, Zhang Z, Tune N, Li M, Solar P, Chen X, Wang D, Tang BZ. Aggregation-enhanced theranostics: AIE sparkles in biomedical discipline. Mixture. 2020;1:80–106.


    Google Scholar
     

  • 39.

    Han Z, Zhao X, Peng P, Li S, Zhang C, Cao M, Li Okay, Wang Z-Y, Zang S-Q. Intercluster aurophilicity-driven aggregation lighting circularly polarized luminescence of chiral gold clusters. Nano Res. 2020;13:3248–52.

    CAS 

    Google Scholar
     

  • 40.

    Zhang MM, Dong XY, Wang ZY, Li HY, Li SJ, Zhao X, Zang SQ. AIE triggers the circularly polarized luminescence of atomically exact enantiomeric copper(I) alkynyl clusters. Angew Chem, Int Ed. 2020;59:10052–8.

    CAS 

    Google Scholar
     

  • 41.

    Sugiuchi M, Maeba J, Okubo N, Iwamura M, Nozaki Okay, Konishi Okay. Aggregation-induced fluorescence-to-phosphorescence switching of molecular gold clusters. J Am Chem Soc. 2017;139:17731–4.

    CAS 
    PubMed 

    Google Scholar
     

  • 42.

    Xiao Y, Wu Z, Yao Q, Xie J. Luminescent steel nanoclusters: biosensing methods and bioimaging purposes. Mixture. 2021;2:114–32.


    Google Scholar
     

  • 43.

    Wu ZN, Yao QF, Zang SQ, Xie JP. Aggregation-induced emission in luminescent steel nanoclusters. Natl Sci Rev. 2021;8: nwaa208.

    PubMed 

    Google Scholar
     

  • 44.

    Wang D, Lee MMS, Shan G, Kwok RTK, Lam JWY, Su H, Cai Y, Tang BZ. Extremely environment friendly photosensitizers with far-red/near-infrared aggregation-induced emission for in vitro and in vivo most cancers theranostics. Adv Mater. 2018;30: e1802105.

    PubMed 

    Google Scholar
     

  • 45.

    Xu S, Yuan Y, Cai X, Zhang CJ, Hu F, Liang J, Zhang G, Zhang D, Liu B. Tuning the singlet-triplet power hole: a singular method to environment friendly photosensitizers with aggregation-induced emission (AIE) traits. Chem Sci. 2015;6:5824–30.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • 46.

    Lu Y, Xu YJ, Zhang GB, Ling D, Wang MQ, Zhou Y, Wu YD, Wu T, Hackett MJ, Hyo Kim B. Iron oxide nanoclusters for T1 magnetic resonance imaging of non-human primates. Nat Biomed Eng. 2017;1:637–43.

    CAS 
    PubMed 

    Google Scholar
     

  • 47.

    Gao S, Li T, Guo Y, Solar C, Xianyu B, Xu H. Selenium-containing nanoparticles mix the NK cells mediated immunotherapy with radiotherapy and chemotherapy. Adv Mater. 2020;32:1907568.

    CAS 

    Google Scholar
     

  • 48.

    Dai J, Li Y, Lengthy Z, Jiang R, Zhuang Z, Wang Z, Zhao Z, Lou X, Xia F, Tang BZ. Environment friendly near-infrared photosensitizer with aggregation-induced emission for imaging-guided photodynamic remedy in a number of xenograft tumor fashions. ACS Nano. 2020;14:854–66.

    CAS 
    PubMed 

    Google Scholar
     

  • 49.

    Guo B, Sheng Z, Hu D, Liu C, Zheng H, Liu B. By scalp and cranium NIR-II photothermal remedy of deep orthotopic mind tumors with exact photoacoustic imaging steerage. Adv Mater. 2018;30:1802591.


    Google Scholar
     

  • 50.

    Liang G, Jin X, Zhang S, Xing D. RGD peptide-modified fluorescent gold nanoclusters as extremely environment friendly tumor-targeted radiotherapy sensitizers. Biomaterials. 2017;144:95–104.

    CAS 
    PubMed 

    Google Scholar
     

  • 51.

    Liu J, Wu M, Pan Y, Duan Y, Dong Z, Chao Y, Liu Z, Liu B. Biodegradable nanoscale coordination polymers for focused tumor mixture remedy with oxidative stress amplification. Adv Funct Mater. 2020;30:1908865.

    CAS 

    Google Scholar
     

  • 52.

    Xiong X, Xu Z, Huang H, Wang Y, Zhao J, Guo X, Zhou S. A NIR gentle triggered disintegratable nanoplatform for enhanced penetration and chemotherapy in deep tumor tissues. Biomaterials. 2020;245: 119840.

    CAS 
    PubMed 

    Google Scholar
     

  • 53.

    Zhang J, Yang C, Zhang R, Chen R, Zhang Z, Zhang W, Peng SH, Chen X, Liu G, Hsu CS, Lee CS. Biocompatible D-A semiconducting polymer nanoparticle with light-harvesting unit for extremely efficient photoacoustic imaging guided photothermal remedy. Adv Funct Mater. 2017;27:1605094.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • 54.

    Ma N, Wu FG, Zhang X, Jiang YW, Jia HR, Wang HY, Li YH, Liu P, Gu N, Chen Z. Form-dependent radiosensitization impact of gold nanostructures in most cancers radiotherapy: comparability of gold nanoparticles, nanospikes, and nanorods. ACS Appl Mater Interfaces. 2017;9:13037–48.

    CAS 
    PubMed 

    Google Scholar
     

  • 55.

    Zhang XD, Wu D, Shen X, Chen J, Solar YM, Liu PX, Liang XJ. Measurement-dependent radiosensitization of PEG-coated gold nanoparticles for most cancers radiation remedy. Biomaterials. 2012;33:6408–19.

    CAS 
    PubMed 

    Google Scholar
     

  • 56.

    Dong X, Cheng R, Zhu S, Liu H, Zhou R, Zhang C, Chen Okay, Mei L, Wang C, Su C. A heterojunction structured WO2.9-WSe2 nanoradiosensitizer will increase native tumor ablation and checkpoint blockade immunotherapy upon low radiation dose. ACS Nano. 2020;14:5400–16.

    CAS 
    PubMed 

    Google Scholar
     

  • 57.

    Ni Okay, Lan G, Chan C, Quigley B, Lu Okay, Aung T, Guo N, La Riviere P, Weichselbaum RR, Lin W. Nanoscale metal-organic frameworks improve radiotherapy to potentiate checkpoint blockade immunotherapy. Nat Commun. 2018;9:2351.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • 58.

    Susanne CSB, Michael L, Boris P. Quantitative sensing and signalling of single-stranded DNA through the DNA harm response. Nat Commun. 2019;10:944.


    Google Scholar
     

  • 59.

    An D, Su J, Weber JK, Gao X, Zhou R, Li J. A Peptide-coated gold nanocluster displays distinctive habits in protein exercise inhibition. J Am Chem Soc. 2015;137:8412–8.

    CAS 
    PubMed 

    Google Scholar
     

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