Saturday, November 7, 2026
HomeNanotechnologyA drug-free nanozyme for mitigating oxidative stress and inflammatory bowel illness |...

A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel illness | Journal of Nanobiotechnology

[ad_1]

  • Kudelka MR, Stowell SR, Cummings RD, Neish AS. Intestinal epithelial glycosylation in homeostasis and intestine microbiota interactions in IBD. Nat Rev Gastroenterol Hepatol. 2020;17(10):597–617.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel illness. Nature. 2011;474(7351):307–17.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lee B-C, Lee JY, Kim J, Yoo JM, Kang I, Kim J-J, Shin N, Kim DJ, Choi SW, Kim D, Hong BH, Kang Ok-S. Graphene quantum dots as anti-inflammatory remedy for colitis. Sci Adv. 2020;6(18):eaaz2630.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nielsen OH. New methods for therapy of inflammatory bowel illness. Entrance Med. 2014;1:3.


    Google Scholar
     

  • Marafini I, Sedda S, Dinallo V, Monteleone G. Inflammatory cytokines: from discoveries to therapies in IBD. Knowledgeable Opin Biol Th. 2019;19(11):1207–17.

    CAS 

    Google Scholar
     

  • de Souza HSP, Fiocchi C. Immunopathogenesis of IBD: present state-of-the-art. Nat Rev Gastroenterol Hepatol. 2016;13(1):13–27.

    PubMed 

    Google Scholar
     

  • Hamilton JA. Colony-stimulating components in irritation and autoimmunity. Nat Rev Immunol. 2008;8(7):533–44.

    CAS 
    PubMed 

    Google Scholar
     

  • Zhu H, Li YR. Oxidative stress and redox signaling mechanisms of inflammatory bowel illness: up to date experimental and medical proof. Exp Biol Med. 2012;237(5):474–80.

    CAS 

    Google Scholar
     

  • Rezaie A, Parker RD, Abdollahi M. Oxidative stress and pathogenesis of inflammatory bowel illness: an epiphenomenon or the trigger? Dig Dis Sci. 2007;52(9):2015–21.

    PubMed 

    Google Scholar
     

  • Pereira C, Grácio D, Teixeira JP, Magro F. Oxidative stress and DNA injury: implications in inflammatory bowel illness. Inflamm Bowel Dis. 2015;21(10):2403–17.

    PubMed 

    Google Scholar
     

  • Tang Y, Shi Y, Gao Y, Xu X, Han T, Li J, Liu C. Oxytocin system alleviates intestinal irritation by regulating macrophages polarization in experimental colitis. Clin Sci. 2019;133(18):1977–92.

    CAS 

    Google Scholar
     

  • Zhang G, Ma L, Bai L, Li M, Guo T, Tian B, He Z, Fu Q. Inflammatory microenvironment-targeted nanotherapies. J Management Launch. 2021;334:114–26.

    CAS 
    PubMed 

    Google Scholar
     

  • Friedrich M, Pohin M, Powrie F. Cytokine networks within the pathophysiology of inflammatory bowel illness. Immunity. 2019;50(4):992–1006.

    CAS 
    PubMed 

    Google Scholar
     

  • Zhang B, Bailey WM, McVicar AL, Gensel JC. Age will increase reactive oxygen species manufacturing in macrophages and potentiates oxidative injury after spinal wire harm. Neurobiol Ageing. 2016;47:157–67.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li F, Qiu Y, Xia F, Solar H, Ling D. Twin detoxing and inflammatory regulation by ceria nanozymes for drug-induced liver harm remedy. Nano At present. 2020;35:100925.

    CAS 

    Google Scholar
     

  • Zeng F, Wu Y, Li X, Ge X, Guo Q, Lou X, Cao Z, Hu B, Lengthy NJ, Mao Y, Li C. Customized-made ceria nanoparticles present a neuroprotective impact by modulating phenotypic polarization of the microglia. Angew Chem Int Ed. 2018;57(20):5808–12.

    CAS 

    Google Scholar
     

  • Weng Q, Solar H, Fang C, Xia F, Liao H, Lee J, Wang J, Xie A, Ren J, Guo X, Li F, Yang B, Ling D. Catalytic exercise tunable ceria nanoparticles forestall chemotherapy-induced acute kidney harm with out interference with chemotherapeutics. Nat Commun. 2021;12(1):1436.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ni D, Wei H, Chen W, Bao Q, Rosenkrans ZT, Barnhart TE, Ferreira CA, Wang Y, Yao H, Solar T, Jiang D, Li S, Cao T, Liu Z, Engle JW, Hu P, Lan X, Cai W. Ceria nanoparticles meet hepatic ischemia-reperfusion harm: the proper imperfection. Adv Mater. 2019;31(40):1902956.

    CAS 

    Google Scholar
     

  • Zhao S, Li Y, Liu Q, Li S, Cheng Y, Cheng C, Solar Z, Du Y, Butch CJ, Wei H. An orally administered CeO2@Montmorillonite nanozyme targets irritation for inflammatory bowel illness remedy. Adv Funct Mater. 2020;30(45):2004692.

    CAS 

    Google Scholar
     

  • Soh M, Kang D-W, Jeong H-G, Kim D, Kim DY, Yang W, Track C, Baik S, Choi I-Y, Ki S-Ok, Kwon HJ, Kim T, Kim CK, Lee S-H, Hyeon T. Ceria-Zirconia nanoparticles as an enhanced multi-antioxidant for sepsis therapy. Angew Chem Int Ed. 2017;56(38):11399–403.

    CAS 

    Google Scholar
     

  • Thangudu S, Su C-H. Peroxidase mimetic nanozymes in most cancers phototherapy: progress and views. Biomolecules. 2021;11:7.


    Google Scholar
     

  • Ota M, Tanaka Y, Nakagawa I, Jiang J-J, Arima Y, Kamimura D, Onodera T, Iwasaki N, Murakami M. Function of chondrocytes within the growth of rheumatoid arthritis by way of transmembrane protein 147–mediated NF-κB activation. Arthr Rheumatol. 2020;72(6):931–42.

    CAS 

    Google Scholar
     

  • Zhao Y, Yang Y, Zhang J, Wang R, Cheng B, Kalambhe D, Wang Y, Gu Z, Chen D, Wang B, Huang Y. Lactoferrin-mediated macrophage concentrating on supply and patchouli alcohol-based therapeutic technique for inflammatory bowel ailments. Acta Pharm Sin B. 2020;10(10):1966–76.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Takkinen JS, López-Picón FR, Al Majidi R, Eskola O, Krzyczmonik A, Keller T, Löyttyniemi E, Solin O, Rinne JO, Haaparanta-Solin M. Mind power metabolism and neuroinflammation in ageing APP/PS1–21 mice utilizing longitudinal 18F-FDG and 18F-DPA-714 PET imaging. J Cereb Blood Movement Metab. 2016;37(8):2870–82.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Abourbeh G, Thézé B, Maroy R, Dubois A, Brulon V, Fontyn Y, Dollé F, Tavitian B, Boisgard R. Imaging microglial/macrophage activation in spinal cords of experimental autoimmune encephalomyelitis rats by positron emission tomography utilizing the mitochondrial 18 kDa translocator protein radioligand 18FDPA-714. J Neurosci. 2012;32(17):5728.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guo Q. A TSPO PET imaging examine to judge irritation in Crohn’s illness. J Nucl Med. 2018;59(complement 1):1585.


    Google Scholar
     

  • Bernards N, Pottier G, Thézé B, Dollé F, Boisgard R. In vivo analysis of inflammatory bowel illness with assistance from μPET and the translocator protein 18 kDa radioligand [18F]DPA-714. Mol Imag Biol. 2015;17(1):67–75.

    CAS 

    Google Scholar
     

  • Ueno A, Jeffery L, Kobayashi T, Hibi T, Ghosh S, Jijon H. Th17 plasticity and its relevance to inflammatory bowel illness. J Autoimmun. 2018;87:38–49.

    CAS 
    PubMed 

    Google Scholar
     

  • Tao J-H, Duan J-A, Zhang W, Jiang S, Guo J-M, Wei D-D. Polysaccharides from chrysanthemum morifolium ramat ameliorate colitis rats by way of regulation of the metabolic profiling and NF-κ B/TLR4 and IL-6/JAK2/STAT3 signaling pathways. Entrance Pharmacol. 2018;9:746.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang J, Pan Y, Cao Y, Zhou W, Lu J. Salidroside regulates the expressions of IL-6 and defensins in LPS-activated intestinal epithelial cells by means of NF-κB/MAPK and STAT3 pathways. Iran J Primary Med Sci. 2019;22(1):31–7.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang S, Lin Y, Yuan X, Li F, Guo L, Wu B. REV-ERBα integrates colon clock with experimental colitis by means of regulation of NF-κB/NLRP3 axis. Nat Commun. 2018;9(1):4246.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Johnson DE, O’Keefe RA, Grandis JR. Concentrating on the IL-6/JAK/STAT3 signalling axis in most cancers. Nat Rev Clin Oncol. 2018;15(4):234.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen L, You Q, Hu L, Gao J, Meng Q, Liu W, Wu X, Xu Q. The antioxidant procyanidin reduces reactive oxygen species signaling in macrophages and ameliorates experimental colitis in mice. Entrance Immunol. 2018;8:1910.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Silva FAR, Rodrigues BL, Ayrizono MLS, Leal RF. The immunological foundation of inflammatory bowel illness. Gastroent Res Pract. 2016;2016:2097274.


    Google Scholar
     

  • Papamichael Ok, Gils A, Rutgeerts P, Levesque BG, Vermeire S, Sandborn WJ, VandeCasteele N. Function for therapeutic drug monitoring throughout induction remedy with TNF antagonists in IBD: evolution within the definition and administration of major nonresponse. Inflamm Bowel Dis. 2015;21(1):182–97.

    PubMed 

    Google Scholar
     

  • Liu Y, Cheng Y, Zhang H, Zhou M, Yu Y, Lin S, Jiang B, Zhao X, Miao L, Wei C-W, Liu Q, Lin Y-W, Du Y, Butch CJ, Wei H. Built-in cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory remedy. Sci Adv. 2020;6(29):eabb2695.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang Q, Wei H, Zhang Z, Wang E, Dong S. Nanozyme: an rising different to pure enzyme for biosensing and immunoassay, TrAC. Developments Anal Chem. 2018;105:218–24.

    CAS 

    Google Scholar
     

  • Li Y, He X, Yin J-J, Ma Y, Zhang P, Li J, Ding Y, Zhang J, Zhao Y, Chai Z, Zhang Z. Acquired superoxide-scavenging capability of ceria nanoparticles. Angew Chem Int Ed. 2015;54(6):1832–5.

    CAS 

    Google Scholar
     

  • Karakoti AS, Das S, Thevuthasan S, Seal S. PEGylated inorganic nanoparticles. Angew Chem Int Ed. 2011;50(9):1980–94.

    CAS 

    Google Scholar
     

  • Verma A, Uzun O, Hu Y, Hu Y, Han H-S, Watson N, Chen S, Irvine DJ, Stellacci F. Floor-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles. Nat Mater. 2008;7(7):588–95.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Torrano AA, Herrmann R, Strobel C, Rennhak M, Engelke H, Reller A, Hilger I, Wixforth A, Bräuchle C. Cell membrane penetration and mitochondrial concentrating on by platinum-decorated ceria nanoparticles. Nanoscale. 2016;8(27):13352–67.

    CAS 
    PubMed 

    Google Scholar
     

  • Kwon HJ, Kim D, Search engine optimization Ok, Kim YG, Han SI, Kang T, Soh M, Hyeon T. Ceria nanoparticle programs for selective scavenging of mitochondrial, intracellular, and extracellular reactive oxygen species in Parkinson’s Illness. Angew Chem Int Ed. 2018;57(30):9408–12.

    CAS 

    Google Scholar
     

  • Singh S, Ly A, Das S, Sakthivel TS, Barkam S, Seal S. Cerium oxide nanoparticles on the nano-bio interface: size-dependent mobile uptake. Artif Cells Nanomed Biotechnol. 2018;46(sup3):S956–63.

    CAS 
    PubMed 

    Google Scholar
     

  • Hashimoto S, Shimizu Ok, Shibata H, Kanayama S, Tanabe R, Onoda H, Matsunaga N, Sakaida I. Utility of computed tomographic enteroclysis/enterography for the evaluation of mucosal therapeutic in Crohn’s illness. Gastroent Res Pract. 2013;2013:984916.


    Google Scholar
     

  • Higgins PDR, Caoili E, Zimmermann M, Bhuket TP, Sonda PL, Manoogian B, Platt JF, Zimmermann EM. Computed tomographic enterography provides info to medical administration in small bowel Crohn’s illness. Inflamm Bowel Dis. 2007;13(3):262–8.

    PubMed 

    Google Scholar
     

  • Thiel A, Heiss W-D. Imaging of microglia activation in stroke. Stroke. 2011;42(2):507–12.

    PubMed 

    Google Scholar
     

  • Ogura H, Murakami M, Okuyama Y, Tsuruoka M, Kitabayashi C, Kanamoto M, Nishihara M, Iwakura Y, Hirano T. Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop by way of interleukin-6 induction. Immunity. 2008;29(4):628–36.

    CAS 
    PubMed 

    Google Scholar
     

  • Casals E, Zeng M, Parra-Robert M, Fernández-Varo G, Morales-Ruiz M, Jiménez W, Puntes V, Casals G. Cerium oxide nanoparticles: advances in biodistribution, toxicity, and preclinical exploration. Small. 2020;16(20):1907322.

    CAS 

    Google Scholar
     

  • Wang M, Zeng F, Ning F, Wang Y, Zhou S, He J, Li C, Wang C, Solar X, Zhang D, Xiao J, Hu P, Reilly S, Xin H, Xu X, Zhang X. Ceria nanoparticles ameliorate renal fibrosis by modulating the stability between oxidative phosphorylation and cardio glycolysis. J Nanobiotechnol. 2022;20(1):3.

    CAS 

    Google Scholar
     

  • Park Ok, Park J, Lee H, Choi J, Yu W-J, Lee J. Toxicity and tissue distribution of cerium oxide nanoparticles in rats by two totally different routes: single intravenous injection and single oral administration. Arch Pharm Res. 2018;41(11):1108–16.

    CAS 
    PubMed 

    Google Scholar
     

  • Graham UM, Tseng MT, Jasinski JB, Yokel RA, Unrine JM, Davis BH, Dozier AK, Hardas SS, Sultana R, Grulke EA, Butterfield DA. In vivo processing of ceria nanoparticles inside liver: influence on free-radical scavenging exercise and oxidative stress. ChemPlusChem. 2014;79(8):1083–8.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Modrzynska J, Berthing T, Ravn-Haren G, Kling Ok, Mortensen A, Rasmussen RR, Larsen EH, Saber AT, Vogel U, Loeschner Ok. In vivo-induced measurement transformation of cerium oxide nanoparticles in each lung and liver doesn’t have an effect on long-term hepatic accumulation following pulmonary publicity. PLoS ONE. 2018;13(8):e0202477.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • [ad_2]

    RELATED ARTICLES

    LEAVE A REPLY

    Please enter your comment!
    Please enter your name here

    Most Popular

    Recent Comments